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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Epigenetic Mechanisms Controlling Human Leukemia Stem Cells and Therapy Resistance
[Nature Communications] Investigators applied functional genomic profiling to diverse human leukemias, including high-risk MLL- and NUP98-rearranged specimens, using label tracing in vivo.
Photothermal Treatment of Prostate Tumor with Micellar Indocyanine Green and Napabucasin to Co-Ablate Cancer Cells and Cancer Stem Cells
[Journal of Controlled Release] Scientists presented micellar indocyanine green and napabucasin that co-ablated cancer cells and cancer stem cells via photothermal therapy for the treatment of prostate tumors.
Inhibition of DNA Polymerase Eta-Mediated Translesion DNA Synthesis with Small Molecule Sensitises Ovarian Cancer Stem-Like Cells to Chemotherapy
[British Journal of Pharmacology] Researchers screened and identified chrysin as a small-molecule inhibitor that sensitized ovarian cancer stem-like cells to cisplatin treatment by inhibiting DNA polymerase eta-mediated translesion DNA synthesis.
Efficient and Discriminative Isolation of Circulating Cancer Stem Cells and Non-Stem-like Circulating Tumor Cells Using a Click-Handle-Loaded M13 Phage-Based Surface
[Analytical Chemistry] Investigators developed a novel circulating tumor cell isolation approach that integrates cell metabolic chemical tagging with a click-handle-loaded M13 phage-based surface (CHPhace).
ABCB1 Confers Resistance to Carboplatin by Accumulating Stem-Like Cells in the G2/M Phase of the Cell Cycle in P53null Ovarian Cancer
[Cell Death Discovery] Researchers demonstrated that acquired resistance to carboplatin in SKOV3 harboring a p53null mutation, but not in OVCAR3 with a p53R248Q, induced a significant portion of cells accumulated in the G2/M phase of the cell cycle, where cells highly expressed stemness marker with elevated proliferative capacity, which they believed was reversed by ABCB1 inhibition to the levels observed in non-resistant parental cells.
Immune Checkpoints Regulate Acute Myeloid Leukemia Stem Cells
[Leukemia] The authors summarized recent data on selected immune checkpoints of the immunoglobulin superfamily and the tumor necrosis factor receptor superfamily that have a documented role in the regulation of leukemia stem cells, independent of their immune regulatory role, and might become novel therapeutic targets.
AccuStem Sciences to Offer its MSC Blood Test to Lung Cancer Screening Programs in the United States
[AcuStem Sciences, Inc.] AccuStem Sciences, Inc. announced plans to launch its microRNA Signature Classifier (MSC) blood test for use in the more than 1.6 million US patients diagnosed each year with nodules as part of current lung cancer screening protocols.
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
[Cancer Discovery] Using a novel circulating tumor cell (CTC) isolation approach, researchers collected 273 CTC samples from 117 patients with metastatic prostate cancer for RNA sequencing.
In Silico Analysis Unveiling the Role of Cancer Stem Cells in Immunotherapy Resistance of Immune Checkpoint-High Pancreatic Adenocarcinoma
[Scientific Reports] By mining cancer datasets using R2, available clinical trial data, and Kaplan–Meier analysis from GEPIA depicted that unlike low-responder cancers, high-responder cancers furnish higher immune checkpoint expression, that upon lowering may provide better prognosis.
Combined Targeting of Glioblastoma Stem Cells of Different Cellular States Disrupts Malignant Progression
[Nature Communications] Researchers found that classical (CL) and mesenchymal (MES) glioblastoma (GBM) stem cells were enriched in reactive immune region and high CL-MES signature informed poor prognosis in GBM.
The FOXP1-ABCG2 Axis Promotes the Proliferation of Cancer Stem Cells and Induces Chemoresistance in Pancreatic Cancer
[Cancer Gene Therapy] Investigators found that the expression of the transcription factor Forkhead Box P1 (FOXP1) was elevated in chemoresistant pancreatic cancer and crucial for establishing CSC characteristics.
Gastroesophageal Circulating Tumor Cell Crosstalk with Peripheral Immune System Guides CTC Survival and Proliferation
[Cell Death & Disease] Scientists established an in-vitro co-culture system consisting of immune cells and circulating tumor cells (CTCs) from the same patient, which increased the success rate in the establishment of CTC-derived long-term cell cultures.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
